5/30/2023 0 Comments Loopy alcohol![]() Collectively, how these interact to affect the overall rate of an enzymatic process is called kinetics. The rate at which substrate becomes product is dependent on (1) how much product there is (2) how much substrate there is and (3) how much enzyme there is (for the above analogy, you can think of the enzyme as the hammer). For simplicity's sake, I'll focus on the CYP first.Ī bit of basic biochemistry: Your stereotypical enzymatic process has one or more substrate (the starting material think nails, wood) and one or more products (what you end up with think "table"). The first two are the indirect ones, the last is the direct one. The three main ones are alcohol dehydrogenase (ADH) aldehyde dehydrogenase (ALDH) and some of the cytochromes P450 (CYP(somethingsomething)). Oxygen levels drop in the liver because the enzymes that break down ethanol use oxygen either directly or indirectly. This long-term hypoxia contributes to the liver disease you see in alcoholics. Even light alcohol consumption increases oxygen demand in the liver and can cause hypoxia. In fact, hepatocytes (liver cells) become hypoxic (have low oxygen levels) with chronic alcohol consumption. Oxygen is required for alcohol metabolism in the liver. We set up a controlled study one night, but it kind of fell apart. All the locals I talked to said they had more tolerance when they went elsewhere, and every attendee that I talked to had noticed an diminished capacity. After discussing it with other attendees and a few locals, it turned out to at least look like a real effect. At first, I attributed it to the notion that the awesome selection of beers you have in Denver made me lose track of how many I had. For example, the three beers I had at the Cheeky Monk (sweet bar on Colfax, BTW) made me unbalanced when I stood up. I noticed my alcohol tolerance was dramatically decreased, as did many of the people I was there with. Last month, I was in Denver for a conference. Here, I shall give you more anecdotes and a bit more thought out speculation. I'm so happy I'm done, and have learned enough to appreciate what sobriety feels like.There are not a lot of papers on the specific subject, and (of course) the internet is full of anecdotes and speculation. ![]() I'd rather be alone the rest of my life than to endure that stress for one more evening. Some of the most traumatic experiences I've ever had were due to someone else's alcohol usage, and I swear to God I'll never be around it again. I don't want to be around a person under the influence ever again. The amount of stress that comes from it all is bewildering and I'm shocked I haven't had a heart attack. I'll never be that person ever the hell again. I don't want to be around anyone, or anything that has a sliver to do with alcohol, kratom, phenibut- anything. Not now, not after experiencing sobriety as an adult. His drinking, and my BPD (at the time not diagnosed) was going to be the end of me. I suddenly realized that it's too stressful- especially to be drinking with my partner. I had a couple drinks this last weekend and it was great for about an hour. I have a completely different perspective on drugs now. It's wild to come back down to earth after all of this time. Then, I quit smoking, and within a month, I was on kratom. ![]() ![]() There weren't but less than 6 weeks I was sober from it. Prior to kratom, I smoked pot for years on years consistently. I'm as sober as I've been in about 6 years. I abused phenibut for a very short time period, too I'd rather take kratom for another 4 years instead of taking phenibut at that rate ever the hell again. I almost got off of kratom while I was drinking, but the stress of my SO's drinking problem kept me reliant on it. That was one of the darkest times of my life and my relationship. I abused alcohol for some months at one point as well. I've come down a number of times, but finally had the perfect chance to get off of it for good. I've recently gotten off of kratom after abusing it for four years.
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